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NMDA Receptor Antagonists: Small Molecules and Peptides

NMDA receptors (NMDARs) are members of the glutamate-gated ion-channel family and function in synaptic plasticity, neuronal development and excitotoxicity.

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33 results for "NMDA Receptor Antagonists Small Molecules and Peptides" in Products

33 results for "NMDA Receptor Antagonists Small Molecules and Peptides" in Products

NMDA Receptor Antagonists: Small Molecules and Peptides

NMDA receptors (NMDARs) are members of the glutamate-gated ion-channel family and function in synaptic plasticity, neuronal development and excitotoxicity.

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Potent and selective NMDA receptor antagonist; more active form of DL-AP5

Alternate Names: 2-APV,D-APV,D-2-amino-5-phosphonovalerate
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Purity: ≥98% (HPLC)
Potent and selective NMDA receptor antagonist; more active form of DL-AP5

Non-competitive NMDA receptor antagonist

Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Non-competitive NMDA receptor antagonist

Potent and selective NMDA antagonist

Alternate Names: DL-APV
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid
Purity: ≥98% (HPLC)
Potent and selective NMDA antagonist

Non-competitive NMDA antagonist; also σ ligand

Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Purity: ≥98% (HPLC)
Non-competitive NMDA antagonist; also σ ligand

Non-competitive NMDA antagonist; acts at ion channel site

Alternate Names: Dizocilpine
Chemical Name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
Purity: ≥98% (HPLC)
Non-competitive NMDA antagonist; acts at ion channel site

Potent and selective non-NMDA iGluR antagonist

Alternate Names: Cyanquixaline
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
Purity: ≥98% (HPLC)
Potent and selective non-NMDA iGluR antagonist

Potent and selective NMDA antagonist; acts at glycine site

Alternate Names: PAMQX
Chemical Name: [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid hydrochloride
Purity: ≥98% (HPLC)
Potent and selective NMDA antagonist; acts at glycine site

GluN2B-selective NMDA antagonist

Chemical Name: RS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Purity: ≥98% (HPLC)
GluN2B-selective NMDA antagonist

Potent and selective NMDA antagonist; sodium salt of DL-AP5

Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Purity: ≥98% (HPLC)
Potent and selective NMDA antagonist; sodium salt of DL-AP5

NMDA antagonist; acts at ion channel site

Chemical Name: 3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
NMDA antagonist; acts at ion channel site

Highly potent NMDA antagonist

Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Purity: ≥98% (HPLC)
Highly potent NMDA antagonist

Potent and noncompetitive NMDA antagonist

Alternate Names: CNS 1102
Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Purity: ≥98% (HPLC)
Potent and noncompetitive NMDA antagonist

Potent NMDA antagonist; more active enantiomer of (RS)-CPP

Chemical Name: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Potent NMDA antagonist; more active enantiomer of (RS)-CPP

NMDA antagonist; acts at glycine site

Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
NMDA antagonist; acts at glycine site

Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid

Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid

Potent and selective NMDA antagonist; acts at the glycine site

Alternate Names: GV 150526A
Chemical Name: 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Potent and selective NMDA antagonist; acts at the glycine site

Non-competitive and GluN2C/GluN2D-selective NMDA antagonist

Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Purity: ≥98% (HPLC)
Non-competitive and GluN2C/GluN2D-selective NMDA antagonist

Potent and GluN2A-selective NMDA antagonist

Chemical Name: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Purity: ≥98% (HPLC)
Potent and GluN2A-selective NMDA antagonist

NMDA antagonist; less active enantiomer of (+)-MK 801

Chemical Name: (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Purity: ≥98% (HPLC)
NMDA antagonist; less active enantiomer of (+)-MK 801

Potent competitive NMDA antagonist

Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Potent competitive NMDA antagonist

Potent NMDA antagonist

Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Potent NMDA antagonist

Potent and selective NMDA antagonist

Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Purity: ≥98% (HPLC)
Potent and selective NMDA antagonist

GluN2C/GluN2D-selective NMDA antagonist

Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
Purity: ≥97% (HPLC)
GluN2C/GluN2D-selective NMDA antagonist

GluN1/GluN2A-selective NMDA antagonist

Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Purity: ≥98% (HPLC)
GluN1/GluN2A-selective NMDA antagonist

Potent competitive NMDA antagonist

Alternate Names: Midafotel,SDZ EAA 494
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Potent competitive NMDA antagonist
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