Ifenprodil hemitartrate

Name: Ifenprodil hemitartrate
Brand: Tocris Bioscience
SKU: 0545

Tocris Bioscience, part of Bio-Techne | Catalog # 0545

Citations (79)

COA / SDS

Non-competitive NMDA antagonist; also σ ligand

Key Product Details

Description:	Non-competitive NMDA antagonist; also σ ligand
Chemical Name:	(1R,2S)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Purity:	≥98% (HPLC)
Molecular Weight:	400.49

View Full Technical Details for Ifenprodil hemitartrate

Technical Data
Citations

Biological Activity for Ifenprodil hemitartrate

Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ₂ ligand displaying about 3-fold selectivity over σ₁ sites.

Technical Data for Ifenprodil hemitartrate

M. Wt	400.49
Formula	C₂₁H₂₇NO₂.½C₄H₆O₆
Storage	Store at RT
Purity	≥98% (HPLC)
PubChem ID	3689
InChi Key	UYNVMODNBIQBMV-UHFFFAOYSA-N
Smiles	OC1=CC=C([C@H]([C@@H](N2CCC(CC3=CC=CC=C3)CC2)C)O)C=C1.OC4=CC=C([C@H]([C@@H](N5CCC(CC6=CC=CC=C6)CC5)C)O)C=C4.O=C([C@H]([C@@H](C(O)=O)O)O)O.OC7=CC=C([C@@H]([C@H](N8CCC(CC9=CC=CC=C9)CC8)C)O)C=C7.OC%10=CC=C([C@@H]([C@H](N%11CCC(CC%12=CC=CC=C%12)CC%11)C)O)C=C%10.O=C([C@@H]([C@H](C(O)=O)O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ifenprodil hemitartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4	10
	DMSO	40.05	100

Preparing Stock Solutions for Ifenprodil hemitartrate

The following data is based on the product molecular weight 400.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.48 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Ifenprodil hemitartrate

References are publications that support the biological activity of the product.

Shalaby Neuroprotective effects of the N-MthD.-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J.Pharmacol.Exp.Ther. 1992 PMID: 1346650
Schoemaker Polyamine-sensitive binding of [³H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex. Eur.J.Pharmacol. 1990 PMID: 2178949
Reynolds and Miller Ifenprodil is a novel type of N-MthD.-aspartate receptor antagonist: interaction with polyamines. Mol.Pharmacol. 1989 PMID: 2555674
Gotti Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia. J.Pharmacol.Exp.Ther. 1988 PMID: 2849668