PEAQX tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5018
Potent and GluN2A-selective NMDA antagonist
Key Product Details
Description
Potent and GluN2A-selective NMDA antagonist
Product Description
PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
542.14
Formula
C17H13BrN3Na4O5P
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
PubChem ID
76900415
InChI Key
QBVOZIDKUFSQIL-LPOFVUTESA-J
SMILES
C[C@@H](C3=CC=C(Br)C=C3)NC(P([O-])([O-])=O)C1=C2C(N=C([O-])C([O-])=N2)=CC=C1.[Na+].[Na+].[Na+].[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.42 | 10 with gentle warming |
Preparing Stock Solutions
for PEAQX tetrasodium salt
The following data is based on the product molecular weight 542.14
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.45 mL | 92.23 mL | 184.45 mL |
| 0.5 mM | 3.69 mL | 18.45 mL | 36.89 mL |
| 1 mM | 1.84 mL | 9.22 mL | 18.45 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Auberson 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg.Med.Chem.Lett. 2002 PMID: 11909726
Product Specific Notices for PEAQX tetrasodium salt
For research use only
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