CNQX

Product Description

CNQX is an AMPA and kainate receptor antagonist (IC₅₀ values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC₅₀ = 25 μM). CNQX can be used to isolate GABA_A receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

CNQX Disodium Salt (Cat. No. 1045) also available.

Solubility

Preparing Stock Solutions for CNQX

The following data is based on the product molecular weight 232.16

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.31 mL	21.54 mL	43.07 mL
5 mM	0.86 mL	4.31 mL	8.61 mL
10 mM	0.43 mL	2.15 mL	4.31 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
• King Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1358390
• Long Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 1990 PMID: 1976402
• Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909