CNQX disodium salt

Name: CNQX disodium salt
Brand: Tocris Bioscience
SKU: 1045
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1045

(3)

Citations (333)

COA / SDS

Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)

Key Product Details

Description:	Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)
Chemical Name:	6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Purity:	≥98% (HPLC)
Molecular Weight:	276.12

View Full Technical Details for CNQX disodium salt

Technical Data
Citations / Reviews (3)

Biological Activity for CNQX disodium salt

CNQX disodium salt is a more water-soluble disodium salt of the AMPA and kainate antagonist CNQX (Cat. No. 0190), which is an AMPA and kainate receptor antagonist (IC₅₀ values are 0.3 μM, 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC₅₀ = 25 μM). CNQX can be used to isolate GABA_A receptor mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

Technical Data for CNQX disodium salt

M. Wt	276.12
Formula	C₉H₂N₄O₄Na₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	479347-85-8
PubChem ID	2821
InChi Key	YCXDDPGRZKUGDG-UHFFFAOYSA-L
Smiles	[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)C#N)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CNQX disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.76	10

Preparing Stock Solutions for CNQX disodium salt

The following data is based on the product molecular weight 276.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.22 mL	181.08 mL	362.16 mL
0.5 mM	7.24 mL	36.22 mL	72.43 mL
1 mM	3.62 mL	18.11 mL	36.22 mL
5 mM	0.72 mL	3.62 mL	7.24 mL

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References for CNQX disodium salt

References are publications that support the biological activity of the product.

Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
King Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1358390
Long Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 1990 PMID: 1976402
Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909