16 results for "Group I mGluR Antagonists Small Molecules and Peptides" in Products
Group I mGluR Antagonists: Small Molecules and Peptides
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu1 and mGlu5. Group I mGluRs are coupled to Gq/11, which activates phospholipase C. They are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing conductance, causing more glutamate to be released from the presynaptic cell. They ...
Competitive group I mGlu antagonist; also weak group II agonist
| Alternate Names: | (S)-4CPG |
| Purity: | ≥98% (HPLC) |
Potent and selective group I mGlu antagonist
| Alternate Names: | UPF 523 |
| Chemical Name: | (RS)-1-Aminoindan-1,5-dicarboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent group I mGlu antagonist
| Chemical Name: | N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide |
| Purity: | ≥98% (HPLC) |
Group I mGlu antagonist
| Chemical Name: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
| Chemical Name: | 2-Methyl-6-(phenylethynyl)pyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective non-competitive mGlu1 antagonist
| Chemical Name: | 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester |
| Purity: | ≥98% (HPLC) |
Highly potent, mGlu1-selective non-competitive antagonist
| Chemical Name: | (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone |
| Purity: | ≥98% (HPLC) |
Potent and selective mGlu5 antagonist
| Chemical Name: | 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective mGlu1 antagonist
| Alternate Names: | MPMQ hydrochloride |
| Chemical Name: | 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective mGlu1a antagonist
| Chemical Name: | (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective mGlu5 antagonist; brain penetrant
| Chemical Name: | 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% (HPLC) |
Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
| Chemical Name: | (RS)-α-Methyl-4-carboxyphenylglycine disodium salt |
| Purity: | ≥98% (HPLC) |
Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
| Chemical Name: | (S)-α-Methyl-4-carboxyphenylglycine |
| Purity: | ≥98% (HPLC) |
Non-selective mGlu antagonist
| Chemical Name: | (RS)-α-Methyl-4-carboxyphenylglycine |
| Purity: | ≥98% (HPLC) |
mGlu1 inverse agonist
| Chemical Name: | (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one |
| Purity: | ≥98% (HPLC) |
mGlu5 antagonist; orally bioavailable and brain penetrant
| Chemical Name: | 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine |
| Purity: | ≥98% (HPLC) |
