(RS)-MCPG
Tocris Bioscience, part of Bio-Techne | Catalog # 0336
Non-selective mGlu antagonist
Product Description
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.S-enantiomer and Sodium Salt also available.
Product Specifications
Molecular Weight
209.20
Formula
C10H11NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(RS)-α-Methyl-4-carboxyphenylglycine
CAS Number
146669-29-6
PubChem ID
1222
InChI Key
DNCAZYRLRMTVSF-UHFFFAOYSA-N
SMILES
NC(C(O)=O)(C)C1=CC=C(C(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 100 |
Preparing Stock Solutions
for (RS)-MCPG
The following data is based on the product molecular weight 209.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.78 mL | 23.90 mL | 47.80 mL |
| 5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 10 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746
- Joly Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 1995 PMID: 7751958
- Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387
Product Specific Notices for (RS)-MCPG
For research use only
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