(RS)-MCPG

Name: ( RS )-MCPG
Brand: Tocris Bioscience
SKU: 0336
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0336

(1)

Citations (27)

COA / SDS

Non-selective mGlu antagonist

Key Product Details

Description:	Non-selective mGlu antagonist
Chemical Name:	(RS)-α-Methyl-4-carboxyphenylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	209.2

View Full Technical Details for (RS)-MCPG

Technical Data
Citations / Reviews (1)

Biological Activity for (RS)-MCPG

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer and Sodium Salt also available.

Technical Data for (RS)-MCPG

M. Wt	209.2
Formula	C₁₀H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	146669-29-6
PubChem ID	1222
InChi Key	DNCAZYRLRMTVSF-UHFFFAOYSA-N
Smiles	NC(C(O)=O)(C)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-MCPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH		100

Preparing Stock Solutions for (RS)-MCPG

The following data is based on the product molecular weight 209.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.78 mL	23.90 mL	47.80 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
10 mM	0.48 mL	2.39 mL	4.78 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for (RS)-MCPG

References are publications that support the biological activity of the product.

Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746
Joly Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 1995 PMID: 7751958
Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387