(S)-MCPG
Tocris Bioscience, part of Bio-Techne | Catalog # 0337
Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
Key Product Details
Description
Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
Product Description
(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.Racemate also available.
Product Specifications
Molecular Weight
209.20
Formula
C10H11NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-α-Methyl-4-carboxyphenylglycine
CAS Number
150145-89-4
PubChem ID
446355
InChI Key
DNCAZYRLRMTVSF-JTQLQIEISA-N
SMILES
N[C@](C)(C(O)=O)C1=CC=C(C(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 20.92 | 100 |
Preparing Stock Solutions
for (S)-MCPG
The following data is based on the product molecular weight 209.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.78 mL | 23.90 mL | 47.80 mL |
| 5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 10 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 1996 PMID: 8730745
- Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387
- Jane Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 1993 PMID: 7689710
- Bordi Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology 1996 PMID: 9025103
Product Specific Notices for (S)-MCPG
For research use only
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