AIDA

Tocris Bioscience, part of Bio-Techne | Catalog # 0904

COA / SDS

Potent and selective group I mGlu antagonist

Key Product Details

Description:	Potent and selective group I mGlu antagonist
Alternative Names:	UPF 523
Chemical Name:	(RS)-1-Aminoindan-1,5-dicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	221.21

View Full Technical Details for AIDA

Technical Data
Citations

Biological Activity for AIDA

AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu_1a), having no effect on group II (mGlu₂) or group III (mGlu₄) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.

Technical Data for AIDA

M. Wt	221.21
Formula	C₁₁H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	168560-79-0
PubChem ID	2071
InChi Key	LSTPKMWNRWCNLS-UHFFFAOYSA-N
Smiles	NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AIDA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	22.12	100

Preparing Stock Solutions for AIDA

The following data is based on the product molecular weight 221.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.52 mL	22.60 mL	45.21 mL
5 mM	0.90 mL	4.52 mL	9.04 mL
10 mM	0.45 mL	2.26 mL	4.52 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

Molarity Calculator

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Reconstitution Calculator

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References for AIDA

References are publications that support the biological activity of the product.

Nielsen Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 1997 PMID: 9196260
Pellicciari 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 1995 PMID: 7562903
Moroni Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 1997 PMID: 9152378