LY 367385
Tocris Bioscience, part of Bio-Techne | Catalog # 1237
Selective mGlu1a antagonist
Product Description
LY 367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors.Licensing Information
Sold with the permission of Eli Lilly and CompanyProduct Specifications
Molecular Weight
209.20
Formula
C10H11NO4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
CAS Number
198419-91-9
PubChem ID
5311261
InChI Key
SGIKDIUCJAUSRD-QMMMGPOBSA-N
SMILES
N[C@H](C(O)=O)C1=C(C)C=C(C(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 10.46 | 50 with gentle warming with sonication |
Preparing Stock Solutions
for LY 367385
The following data is based on the product molecular weight 209.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 9.56 mL | 47.80 mL | 95.60 mL |
| 2.5 mM | 1.91 mL | 9.56 mL | 19.12 mL |
| 5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 25 mM | 0.19 mL | 0.96 mL | 1.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Clark (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett.
- Chapman Anticonvulsant actions of LY 367385 ((+)-methyl-4-carboxyphenylglycine), and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur.J.Pharmacol. 1999 PMID: 10096765
- Salt and Turner Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine. Neuroscience 1998 PMID: 9639261
- Bruno Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept Neuropharmacology 1999 PMID: 10218860
Product Specific Notices for LY 367385
For research use only
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