CPCCOEt

Name: CPCCOEt
Brand: Tocris Bioscience
SKU: 1028
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1028

Citations (248)

COA / SDS

Selective non-competitive mGlu1 antagonist

Key Product Details

Description:	Selective non-competitive mGlu₁ antagonist
Chemical Name:	7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	247.25

View Full Technical Details for CPCCOEt

Technical Data
Citations

Biological Activity for CPCCOEt

CPCCOEt is a hmGlu₁ subtype-selective non-competitive antagonist (IC₅₀ = 6.5 μM). Has no agonist or antagonist activity at hmGlu_{2, 4a, 5a, 7b, 8a} or ionotropic receptors at concentrations of up to 100 μM.

Licensing Information

Sold for research purposes under license from Suntory Ltd.

Compound Libraries for CPCCOEt

CPCCOEt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CPCCOEt

M. Wt	247.25
Formula	C₁₃H₁₃NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	179067-99-3
PubChem ID	6278000
InChi Key	FXCTZFMSAHZQTR-KAMYIIQDSA-N
Smiles	O=C(OCC)C3(C2C3)OC1=CC=CC=C1/C2=N/O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPCCOEt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	1.24	5
	DMSO	24.73	100

Preparing Stock Solutions for CPCCOEt

The following data is based on the product molecular weight 247.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.04 mL	20.22 mL	40.44 mL
5 mM	0.81 mL	4.04 mL	8.09 mL
10 mM	0.40 mL	2.02 mL	4.04 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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Reconstitution Calculator

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References for CPCCOEt

References are publications that support the biological activity of the product.

Litschig CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol.Pharmacol. 1999 PMID: 10051528
Annoura A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett.
Hermans Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor. Neuropharmacology 1998 PMID: 9886688