19 results for "Cell Adhesion Inhibitors Small Molecules and Peptides" in Products
Cell Adhesion Inhibitors: Small Molecules and Peptides
Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.
There are four major families of cell adhesion molecules:
- Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this ...
Selective inhibitor of P-selectin-mediated cell adhesion
| Chemical Name: | 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one |
| Purity: | ≥97% (HPLC) |
Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
| Purity: | ≥95% (HPLC) |
Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
| Purity: | ≥95% (HPLC) |
Sialic acid analog; sialyltransferase inhibitor
| Chemical Name: | 5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate |
| Purity: | ≥97% (HPLC) |
Potent inhibitor of the LFA-1/ICAM interaction
| Chemical Name: | 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
| Purity: | ≥95% (HPLC) |
Potent and selective α1β1 inhibitor
| Purity: | ≥95% (HPLC) |
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
| Chemical Name: | 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
| Chemical Name: | N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of the LFA-1/ICAM-1 interaction
| Chemical Name: | (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Selective α4β1 (VLA-4) inhibitor
| Purity: | ≥95% (HPLC) |
Integrin binding sequence; inhibits integrin receptor function
| Purity: | ≥95% (HPLC) |
Antiangiogenic. Heparanase inhibitor
| Chemical Name: | 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid |
| Purity: | ≥97% (HPLC) |
Disrupts MTDH and SND1 interaction, enhances immune surveillance
| Chemical Name: | 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Heparin sulfate antagonist
| Chemical Name: | N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of E-selectin and ICAM-1 expression
| Chemical Name: | 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
α4β1 (VLA-4) antagonist
| Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity: | ≥98% (HPLC) |
ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice
| Chemical Name: | N-[4-[7-Cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]acetamide |
| Purity: | ≥98% (HPLC) |
