TC-I 15
Tocris Bioscience, part of Bio-Techne | Catalog # 4527
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
Key Product Details
Description
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
Product Description
TC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.Licensing Information
Sold under license from the University of Pennsylvania.Product Specifications
Molecular Weight
520.62
Formula
C23H28N4O6S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
CAS Number
916734-43-5
PubChem ID
90488948
InChI Key
XKLHCUGVLCGKKX-RBUKOAKNSA-N
SMILES
CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.06 | 100 |
Preparing Stock Solutions
for TC-I 15
The following data is based on the product molecular weight 520.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.92 mL | 9.60 mL | 19.21 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.92 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miller Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19141632
- Borza Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 2012 PMID: 22440900
Product Specific Notices for TC-I 15
For research use only
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