Obtustatin

Name: Obtustatin
Brand: Tocris Bioscience
SKU: 4664
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4664

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Citations (11)

COA / SDS

Potent and selective α1β1 inhibitor

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective α1β1 inhibitor

View all Integrin Receptor Inhibitors »

Product Description

Obtustatin is a highly potent integrin α₁β₁ inhibitor (IC₅₀ = 0.8 nM for α₁β₁ binding to type IV collagen). Selective for α₁β₁ over α₂β₁, α_IIbβ₃, α_vβ₃, α₄β₁, α₅β₆, α₉β₁ and α₄β₇. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

Product Specifications

Molecular Weight

4393.07

Formula

C₁₈₄H₂₈₄N₅₂O₅₇S₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

404882-00-4

PubChem ID

90488962

InChI Key

XXWNADNJWWLFFP-UHFFFAOYSA-N

SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CNC3=C1C=CC=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Marcinkiewicz Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo. Cancer Res. 2003 PMID: 12727812
Brown Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth. Int.J.Cancer 2008 PMID: 18712720
Moreno-Murciano Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci. 2003 PMID: 12538900