A 205804
Tocris Bioscience, part of Bio-Techne | Catalog # 2524
Selective inhibitor of E-selectin and ICAM-1 expression
Key Product Details
Description
Selective inhibitor of E-selectin and ICAM-1 expression
Product Description
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.Product Specifications
Molecular Weight
300.39
Formula
C15H12N2OS2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
CAS Number
251992-66-2
PubChem ID
9839311
InChI Key
QQGWEXFLMJGCAL-UHFFFAOYSA-N
SMILES
CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.04 | 100 | |
| Ethanol | 3 | 10 |
Preparing Stock Solutions
for A 205804
The following data is based on the product molecular weight 300.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhu Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J.Med.Chem. 2001 PMID: 11585452
- Zhu Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. J.Org.Chem. 2002 PMID: 11856042
- Stewart Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J.Med.Chem. 2001 PMID: 11300880
Product Specific Notices for A 205804
For research use only
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