Surfen
Tocris Bioscience, part of Bio-Techne | Catalog # 6634
Heparin sulfate antagonist
Key Product Details
Description
Heparin sulfate antagonist
Product Description
Surfen is a heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.Product Specifications
Molecular Weight
445.35
Formula
C21H20N6O.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
CAS Number
5424-37-3
PubChem ID
79472
InChI Key
GKQYGRWQCWWSHN-UHFFFAOYSA-N
SMILES
CC1=NC2=CC=C(C=C2C(N)=C1)NC(NC3=CC=C4N=C(C=C(C4=C3)N)C)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.91 | 20 | |
| DMSO | 8.91 | 20 |
Preparing Stock Solutions
for Surfen
The following data is based on the product molecular weight 445.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.23 mL | 56.14 mL | 112.27 mL |
| 1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
| 2 mM | 1.12 mL | 5.61 mL | 11.23 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huang Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 2018 PMID: 28984039
- Schuksz Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 2008 PMID: 18725627
Product Specific Notices for Surfen
For research use only
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