21 results for "Voltage-gated Sodium Channel Blockers Small Molecules and Peptides" in Products
Voltage-gated Sodium Channel Blockers: Small Molecules and Peptides
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.
Structurally, NaV channels are composed of one pore-forming α-subunit, which may be associated with either one or more β-subunits. α-subunits are composed of four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.
Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
| Alternate Names: | TTx citrate |
| Chemical Name: | (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker
| Alternate Names: | TTx |
| Chemical Name: | (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol |
| Purity: | ≥98% (HPLC) |
Potent and selective Nav1.7 channel blocker
| Chemical Name: | 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker
| Chemical Name: | N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker
| Chemical Name: | N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker; also I2 imidazoline ligand
| Chemical Name: | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
| Chemical Name: | 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride |
| Purity: | ≥98% (HPLC) |
Cardiac Na+ channel blocker. Antiarrhythmic
| Chemical Name: | N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker
| Chemical Name: | 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective NaV1.8 channel blocker; active in vivo
| Chemical Name: | 1-Methyl-1-[4-(4-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-ethylamine |
| Purity: | ≥98% (HPLC) |
NaV channel blocker
| Chemical Name: | N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide |
| Purity: | ≥98% (HPLC) |
Na+ channel blocker; antiarrhythmic agent
| Alternate Names: | Ko 1173 |
| Chemical Name: | 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
ASIC3 channel blocker
| Purity: | ≥95% (HPLC) |
Selective NaV1.7 channel blocker
| Purity: | ≥95% (HPLC) |
Potent and selective NaV1.3 and NaV1.1 channel blocker
| Chemical Name: | α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide |
| Purity: | ≥98% (HPLC) |
Selective NaV1.8 channel blocker
| Chemical Name: | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
| Purity: | ≥98% (HPLC) |
Selective NaV1.5 channel blocker
| Purity: | ≥95% (HPLC) |
Potent voltage-dependent NaV1.8 channel blocker
| Chemical Name: | 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide |
| Purity: | ≥97% (HPLC) |
Potent hNav1.4, rNav1.6 and rNav1.7 channel activator
| Purity: | ≥95% (HPLC) |
NaV blocker; neuroprotective
| Alternate Names: | 619C89 |
| Chemical Name: | 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective Nav1.7 blocker; analgesic
| Chemical Name: | 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide |
| Purity: | ≥98% (HPLC) |
