A 887826

Tocris Bioscience, part of Bio-Techne | Catalog # 4249

Potent voltage-dependent NaV1.8 channel blocker
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Key Product Details

Description

Potent voltage-dependent NaV1.8 channel blocker

View all Voltage-gated Sodium Channel Blockers »

Product Description

A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

Product Specifications

Molecular Weight

480.99

Formula

C26H29ClN4O3

Storage

Store at RT

Purity

≥97% (HPLC)

Chemical Name

5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

CAS Number

1266212-81-0

PubChem ID

46919335

InChI Key

JPJGFWKHSMUKFO-UHFFFAOYSA-N

SMILES

ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.05 50

Preparing Stock Solutions for A 887826

The following data is based on the product molecular weight 480.99

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.16 mL 20.79 mL 41.58 mL
2.5 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
25 mM 0.08 mL 0.42 mL 0.83 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for A 887826

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 887826

For research use only

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