TC-N 1752

Name: TC-N 1752
Brand: Tocris Bioscience
SKU: 4435

Tocris Bioscience, part of Bio-Techne | Catalog # 4435

Citations (4)

COA / SDS

NaV channel blocker

Key Product Details

Description:	Na_V channel blocker
Chemical Name:	N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	516.52

View Full Technical Details for TC-N 1752

Technical Data
Citations

Biological Activity for TC-N 1752

TC-N 1752 is a human Na_V channel inhibitor (IC₅₀ values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNa_V1.7, hNa_V1.3, hNa_V1.4, hNa_V1.5 and hNa_v1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Compound Libraries for TC-N 1752

TC-N 1752 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-N 1752

M. Wt	516.52
Formula	C₂₅H₂₇F₃N₆O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1211866-85-1
PubChem ID	53361524
InChi Key	QLKAFHZJICDACE-UHFFFAOYSA-N
Smiles	CC(C(NC(C)=O)=CC=C4)=C4NC1=NC=NC(N2CCC(OCC3=CC=C(OC(F)(F)F)C=C3)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-N 1752

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.65	100
	1eq. HCl	5.17	10

Preparing Stock Solutions for TC-N 1752

The following data is based on the product molecular weight 516.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for TC-N 1752

References are publications that support the biological activity of the product.

Lin Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells. PLoS One. 2016 PMID: 27556810
Bregman Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 2011 PMID: 21634377