Sipatrigine

Tocris Bioscience, part of Bio-Techne | Catalog # 4044

NaV blocker; neuroprotective
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Key Product Details

Description

NaV blocker; neuroprotective

Alternative Names

619C89

View all Voltage-gated Sodium Channel Blockers »

Product Description

Sipatrigine is a blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).

Product Specifications

Molecular Weight

372.68

Formula

C15H16Cl3N5

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine

CAS Number

130800-90-7

PubChem ID

60803

InChI Key

PDOCBJADCWMDGL-UHFFFAOYSA-N

SMILES

ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.27 100
Ethanol 9.32 25

Preparing Stock Solutions for Sipatrigine

The following data is based on the product molecular weight 372.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.83 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Sipatrigine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Sipatrigine

For research use only

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