Flecainide acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 1470
Cardiac Na+ channel blocker. Antiarrhythmic
Key Product Details
Description
Cardiac Na+ channel blocker. Antiarrhythmic
Product Description
Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.Product Specifications
Molecular Weight
474.40
Formula
C17H20F6N2O3.C2H4O2
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
CAS Number
54143-56-5
PubChem ID
41022
InChI Key
RKXNZRPQSOPPRN-UHFFFAOYSA-N
SMILES
CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.86 | 25 | |
| DMSO | 47.44 | 100 |
Preparing Stock Solutions
for Flecainide acetate
The following data is based on the product molecular weight 474.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rouet and Ducouret Use-and concentration-dependent effects of fleca. in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 1994 PMID: 7526048
- Singh The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 1984 PMID: 6395762
- Banitt Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 1977 PMID: 874956
Product Specific Notices for Flecainide acetate
For research use only
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