Veratridine

Name: Veratridine
Brand: Tocris Bioscience
SKU: 2918
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2918

(2)

Citations (42)

COA / SDS

Voltage-gated Na+ channel opener

Key Product Details

Description:	Voltage-gated Na⁺ channel opener
Chemical Name:	4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity:	≥98% (HPLC)
Molecular Weight:	673.79

View Full Technical Details for Veratridine

Technical Data
Citations / Reviews (2)

Biological Activity for Veratridine

Veratridine is a voltage-gated Na⁺ channel opener; increases intracellular Ca²⁺ with no effect on the Na⁺/Ca²⁺ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na⁺ permeability and depolarizes excitable tissues.

Technical Data for Veratridine

M. Wt	673.79
Formula	C₃₆H₅₁NO₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	71-62-5
PubChem ID	6280
InChi Key	FVECELJHCSPHKY-YFUMOZOISA-N
Smiles	O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Veratridine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.69	50

Preparing Stock Solutions for Veratridine

The following data is based on the product molecular weight 673.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.97 mL	14.84 mL	29.68 mL
2.5 mM	0.59 mL	2.97 mL	5.94 mL
5 mM	0.30 mL	1.48 mL	2.97 mL
25 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for Veratridine

References are publications that support the biological activity of the product.

Maroto Effects of Ca²⁺ channel antagonists on chromaffin cell death and cytosolic Ca²⁺ oscillations induced by veratridine. Eur.J.Pharmacol. 1994 PMID: 7805782
Fekete Mechanism of the persistant sodium current activator veratridine-evoked Ca²⁺ elevation: implication for epilepsy. J.Neurochem. 2009 PMID: 19719824
McKinney Purification, solubility and pK_a of veratridine. Anal.Biochem. 1986 PMID: 3963380