Veratridine
Tocris Bioscience, part of Bio-Techne | Catalog # 2918
Voltage-gated Na+ channel opener
Key Product Details
Description
Voltage-gated Na+ channel opener
Product Description
Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.Product Specifications
Molecular Weight
673.79
Formula
C36H51NO11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
CAS Number
71-62-5
PubChem ID
6280
InChI Key
FVECELJHCSPHKY-YFUMOZOISA-N
SMILES
O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.69 | 50 |
Preparing Stock Solutions
for Veratridine
The following data is based on the product molecular weight 673.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.97 mL | 14.84 mL | 29.68 mL |
| 2.5 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 5 mM | 0.30 mL | 1.48 mL | 2.97 mL |
| 25 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maroto Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 1994 PMID: 7805782
- Fekete Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 2009 PMID: 19719824
- McKinney Purification, solubility and pKa of veratridine. Anal.Biochem. 1986 PMID: 3963380
Product Specific Notices for Veratridine
For research use only
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