QX 314 bromide

Name: QX 314 bromide
Brand: Tocris Bioscience
SKU: 1014
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1014

(1)

Citations (102)

COA / SDS

Na+ channel blocker

Key Product Details

Description:	Na⁺ channel blocker
Chemical Name:	N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Purity:	≥98% (HPLC)
Molecular Weight:	343.31

View Full Technical Details for QX 314 bromide

Technical Data
Citations / Reviews (1)

Biological Activity for QX 314 bromide

QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na⁺ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

Technical Data for QX 314 bromide

M. Wt	343.31
Formula	C₁₆H₂₇N₂OBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	24003-58-5
PubChem ID	9884487
InChi Key	DLHMKHREUTXMCH-UHFFFAOYSA-N
Smiles	[Br-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QX 314 bromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for QX 314 bromide

The following data is based on the product molecular weight 343.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.13 mL
5 mM	0.58 mL	2.91 mL	5.83 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for QX 314 bromide

References are publications that support the biological activity of the product.

Talbot and Sayer Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J.Neurophysiol. 1996 PMID: 8890325
Stichartz The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 1973 PMID: 4541340
Perkins and Wong Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 1995 PMID: 7760149
Alreja and Aghajanian QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain.Res. 1994 PMID: 8205485