Tryptophan Hydroxylase 1/TPH-1 Products
Tryptophan hydroxylase (TPH) belongs to the pterin-dependent, aromatic amino-acid hydroxylase family. It is found in peripheral tissues and pineal gland, and catalyzes the rate-limiting step in serotonin generation from L-tryptophan. The molecule contains two domains, an N-terminal regulatory domain and a C-terminal catalytic domain that contains an iron atom. TPH is constitutively active but unstable. Phosphorylation by PKA at S58 stabilizes the enzyme and increases its activity by 25%. This action is complemented by 14-3-3 proteins that physically interact with phosphorylated TPH to increase both its stability and activity by another 15% to 45% of baseline. Binding of the acidic carboxy terminus of 14-3-3 with the regulatory region of TPH also blocks phosphatase activity directed towards TPH, prolonging its activity.
220 results for "Tryptophan Hydroxylase 1/TPH-1" in Products
220 results for "Tryptophan Hydroxylase 1/TPH-1" in Products
Tryptophan Hydroxylase 1/TPH-1 Products
Tryptophan hydroxylase (TPH) belongs to the pterin-dependent, aromatic amino-acid hydroxylase family. It is found in peripheral tissues and pineal gland, and catalyzes the rate-limiting step in serotonin generation from L-tryptophan. The molecule contains two domains, an N-terminal regulatory domain and a C-terminal catalytic domain that contains an iron atom. TPH is constitutively active but unstable. Phosphorylation by PKA at S58 stabilizes the enzyme and increases its activity by 25%. This action is complemented by 14-3-3 proteins that physically interact with phosphorylated TPH to increase both its stability and activity by another 15% to 45% of baseline. Binding of the acidic carboxy terminus of 14-3-3 with the regulatory region of TPH also blocks phosphatase activity directed towards TPH, prolonging its activity.
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
![Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/nbp3-27018cl1_mouse-tryptophan-hydroxylase-1-tph-1-mab-tph1-7661-cl1-8102025104473.png "Product Feature: CoraFluor Probes for TR-FRET")
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
![Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/nbp3-27019cl1_mouse-tryptophan-hydroxylase-1-tph-1-mab-tph1-7662-cl1-810202510495213.png "Product Feature: CoraFluor Probes for TR-FRET")
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [Alexa Fluor™ Plus 594]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [Alexa Fluor™ Plus 555]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [Alexa Fluor™ Plus 647]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [Alexa Fluor™ Plus 555]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [Alexa Fluor™ Plus 594]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [Alexa Fluor™ Plus 680]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [Alexa Fluor™ Plus 680]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [Alexa Fluor™ Plus 647]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) [Alexa Fluor™ Plus 488]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7661 |
| Applications: | IHC |
Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [Alexa Fluor™ Plus 488]
| Reactivity: | Human |
| Details: | Mouse IgG2 kappa Monoclonal Clone #TPH1/7662 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Tryptophan Hydroxylase 1/TPH-1 Antibody [NBP1-86922]](https://resources.bio-techne.com/images/products/Tryptophan-Hydroxylase-1-TPH-1-Antibody-Immunohistochemistry-Paraffin-NBP1-86922-img0016.jpg "Immunohistochemistry-Paraffin: Tryptophan Hydroxylase 1/TPH-1 Antibody [NBP1-86922]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SC53-07 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: Tryptophan Hydroxylase 1/TPH-1 Antibody (SC53-07) [NBP2-67580]](https://resources.bio-techne.com/images/products/Tryptophan-Hydroxylase-1-TPH-1-Antibody-SC53-07-Western-Blot-NBP2-67580-img0004.jpg "Western Blot: Tryptophan Hydroxylase 1/TPH-1 Antibody (SC53-07) [NBP2-67580]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #007 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #145 |
| Applications: | WB, IP |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB |
![Tryptophan Hydroxylase 1/TPH-1 Antibody [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/af5276cl1_goat-tryptophan-hydroxylase-1-tph-1-pab-corafluor-1-12920251542323.png "Product Feature: CoraFluor Probes for TR-FRET")