Cultrex Basement Membrane Extracts for 2-D and 3-D Cell Culture
Cultrex Basement Membrane Extracts are solubilized extracellular matrices purified from Englebreth-Holm-Swarm (EHS) tumor. They polymerize at 37◦ C to form reconstituted basement membranes that are rich in extracellular matrix proteins, such as laminin, collagen IV, entactin, and heparan sulfate proteoglycans. These specialized sheets of extracellular matrix provide structural support for cells and play an important role in establishing tissue organization by influencing cell adhesion, proliferation, migration, and differentiation. Basement membranes are used to promote and maintain a differentiated phenotype in endothelial cells, epithelial cells, smooth muscle cells, glandular cells, and neurons, and are also used for angiogenesis assays, cell invasion assays, neurite outgrowth assays, and in vivo tumorigenicity assays. Multiple different formats of Cultrex Basement Membrane Extract (BME) are available that have been qualified for specific 2-D and 3-D cell culture applications. The features of each of the different types of basement membrane extract are detailed below. Most are available with or without reduced growth factor content and with or without phenol red.
Extracellular Matrix Portfolio
For additional help selecting or learning how to use Cultrex ECM products, visit the Cultrex ECM Selection and Use Guide.
Cultrex Basement Membrane Extracts
Cultrex ECM Proteins
|Vitronectin||Rat Collagen I||Rat Collagen I, Low Viscosity||Rat Collagen I, 3-D Culture Extract|
|Mouse Laminin I||Laminin I, 3-D Culture Extract||Mouse Collagen IV|
Experience the Quality of Cultrex Before You Buy!
Discover your new favorite matrix today! Experience how Cultrex Basement Membrane Extracts can enhance the performance of your cell cultures.
Customer Success Stories
Asst. Prof. of Pediatrics at the OSU School of Medicine
CSO of MuriGenics Inc.
University of Georgia
Associate Director | Translational Tissue Modeling Institute
Director of the Stem Cell Core Facility | Salk Institute
Hans Clevers Lab | Hubrecht Institute
Proteins for Organoid Culture
Enhance your research outcomes by designing tailor-made culture conditions with the addition of carefully selected cytokines and growth factors.
Induced Pluripotent Stem Cells (iPSC)
iPSCs possess the remarkable ability to differentiate and consequently can provide a foundation for many types of research. ExCellerate™ iPSC Expansion Media readily functions alongside Cultrex ECMs to support robust expansion and maintenance of iPSCs.
Stem cell proliferation and differentiation are controlled by signaling pathways and mechanisms that can be readily manipulated with small molecules, whether alone or in combination with growth factors.