Cultrex Basement Membrane Extract, PathClear Best Seller
Catalog # 3432-010-01 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Features: | Cultrex Basement Membrane Extract (BME) is an extracellular matrix hydrogel that has been used extensively in general cell culture applications to study cell attachment, proliferation, and invasion. |
Key Benefits: |
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Citations for Cultrex Basement Membrane Extract, PathClear (46)
Citations are publications that use Bio-Techne products. Selected citations for Cultrex Basement Membrane Extract, PathClear include:
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Species: Human
Sample Types: Whole Cells
Applications: BioassayZhou et al. (2023-08-15), Hyaluronic acid-based dual network hydrogel with sustained release of platelet-rich plasma as a diabetic wound dressing Carbohydrate polymers
PMID: 37173024 -
Species: Mouse
Sample Types: In Vivo
Applications: BioassayS Ahenkorah et al. (2023-03-29), Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist Nuclear medicine and biology, 2023-0118(0):108338.
PMID: 37018875 -
Species: Rat
Sample Types: In Vivo
Applications: BioassayW Xu et al. (2023-03-28), VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats Heliyon, 2023-09(4):e14626.
PMID: 37095964 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Chen et al. (2022-10-31), Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-kappaB via ANXA1-dependent ubiquitination of NEMO Oncogene, 2022-10(0).
PMID: 36316443 -
Species: Human
Sample Types: Organoid
Applications: BioassayW Yu et al. (2022-09-19), YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma Cancer Gene Therapy, 2022-00(0).
PMID: 36123390 -
Species: Human
Sample Types: Organoid
Applications: BioassayEI Rivas et al. (2022-09-09), Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors Nature Communications, 2022-013(1):5310.
PMID: 36085201 -
Species: Rat
Sample Types: Whole Cell
Applications: Cell CultureMM Schwarz et al. (2022-08-08), Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1 Proceedings of the National Academy of Sciences of the United States of America, 2022-0119(33):e2204706119.
PMID: 35939689 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMR Riccetti et al. (2022-03-08), Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation JCI Insight, 2022-00(0).
PMID: 35113810 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayRN Power et al. (2022-01-27), Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1alpha Delivery for Enhanced Angiogenesis in Tissue Engineering Applications International Journal of Molecular Sciences, 2022-023(3).
PMID: 35163379 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Keller et al. (2021-05-24), Extracellular Matrix Components Regulate Bone Sialoprotein Expression in MDA-MB-231 Breast Cancer Cells Cells, 2021-010(6).
PMID: 34073955 -
Species: Trypanosoma brucei
Sample Types: Whole Cells
F Rojas et al. (2021-04-28), Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro PloS Neglected Tropical Diseases, 2021-015(4):e0009284.
PMID: 33909626 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPK Yang et al. (2021-02-13), Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production Molecular Metabolism, 2021-049(0):101189.
PMID: 33592337 -
MS Hansen et al. (2020-07-14), Specific and Non-Invasive Fluorescent Labelling of Extracellular Vesicles for Evaluation of Intracellular Processing by Intestinal Epithelial Cells Biomedicines, 2020-08(7).
PMID: 32674302 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJ Finlay-Sch et al. (2020-06-23), New generation breast cancer cell lines developed from patient-derived xenografts Breast Cancer Res., 2020-022(1):68.
PMID: 32576280 -
Species: Mouse
Sample Types: Protein
Applications: BioassayT Nybo et al. (2019-06-01), Analysis of protein chlorination by mass spectrometry Redox Biol, 2019-026(0):101236.
PMID: 31181457 -
Species: Mouse
Sample Types: Whole Cells
BL Baechler et al. (2019-04-07), Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation Autophagy, 2019-00(0).
PMID: 30859901 -
Crispel Y et al. (2017-06-04), Involvement of the heparanase procoagulant domain in bleeding and wound healing. J Thromb Haemost, 2017-015(7):1463-1472.
PMID: 28439967 -
Ogawa R et al. (2017-05-15), Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. Biol Open, 2017-06(5):602-618.
PMID: 28373172 -
Sen M et al. (2017-04-17), p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis, 2017-06(4):e320.
PMID: 28414317 -
Willuda J et al. (2017-03-14), Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer. Mol Cancer Ther, 2017-016(5):893-904.
PMID: 28292941 -
Stadem P et al. (2017-02-24), Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. PLoS ONE, 2017-012(2):e0172980.
PMID: 28235023 -
Jones B et al. (2017-02-24), Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior. Mol Cancer Res, 2017-015(6):670-682.
PMID: 28235899 -
Binda E et al. (2016-12-23), Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells. Cancer Res, 2016-177(4):996-1007.
PMID: 28011620 -
(2016-11-14), Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression Proc. Natl. Acad. Sci. U.S.A., 2016-10(0).
PMID: 27849608 -
(2016-08-30), Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2 Cancer Res, 2016-00(0).
PMID: 27578003 -
Jaykumar A et al. (2015-11-04), Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. Am J Physiol Renal Physiol, 2015-1310(2):F183-91.
PMID: 26538436 -
Romero D et al. (2015-10-26), Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-beta-dependent activation of matrix metalloproteases. Carcinogenesis, 2015-137(1):18-29.
PMID: 26503968 -
Sameni M et al. (2015-10-02), Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models. Clin Cancer Res, 2015-122(4):923-34.
PMID: 26432786 -
Beke L et al. (2015-10-02), MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep, 2015-135(6).
PMID: 26431963 -
Clocchiatti A et al. (2015-09-24), The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro. J Cell Sci, 2015-0128(21):3961-76.
PMID: 26403201 -
Kolev V et al. (2014-11-28), PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. Cancer Res, 2014-175(2):446-55.
PMID: 25432176 -
Bittencourt F et al. (2014-08-06), The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. J Virol, 2014-088(20):11811-24.
PMID: 25100846 -
Zhu B et al. (2014-06-04), The nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. J Biol Chem, 2014-0289(29):20102-19.
PMID: 24898257 -
Caccuri et al. (2014-03-12), Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth. J Virol, 2014-088(10):5706-17.
PMID: 24623414 -
Traini S et al. (2014-02-19), Inhibition of tumor growth and angiogenesis by SP-2, an anti-lectin, galactoside-binding soluble 3 binding protein (LGALS3BP) antibody. Mol Cancer Ther, 2014-013(4):916-25.
PMID: 24552775 -
Spinella F et al. (2014-01-28), The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor. Carcinogenesis, 2014-035(4):840-8.
PMID: 24473118 -
Hsu I et al. (2013-10-22), Suppression of ERbeta signaling via ERbeta knockout or antagonist protects against bladder cancer development. Carcinogenesis, 2013-135(3):651-61.
PMID: 24148819 -
Kim S et al. (2013-01-04), Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-alpha in human endometrium and its increased expression in advanced-stage endometriosis. J Clin Endocrinol Metab, 2013-098(2):E238-48.
PMID: 23293332 -
Zhang W et al. (2012-10-29), Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. Proc Natl Acad Sci U S A, 2012-1109(46):18707-12.
PMID: 23112172 -
Krausz E et al. (2012-08-24), Translation of a tumor microenvironment mimicking 3D tumor growth co-culture assay platform to high-content screening. J Biomol Screen, 2012-018(1):54-66.
PMID: 22923784 -
Caccuri F et al. (2012-08-17), HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. Proc Natl Acad Sci U S A, 2012-0109(36):14580-5.
PMID: 22904195 -
Zhang W et al. (2012-08-09), A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment. Blood, 2012-0120(14):2889-98.
PMID: 22879538 -
Munson J et al. (2012-03-28), Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med, 2012-04(127):127ra36.
PMID: 22461640 -
Cieply B et al. (2012-02-29), Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. Cancer Res, 2012-072(9):2440-53.
PMID: 22379025 -
Withana N et al. (2012-01-19), Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res, 2012-072(5):1199-209.
PMID: 22266111 -
Messer W et al. (1988-09-09), Timing and targeting: the biological functions of Dam methylation in E. coli. Cell, 1988-054(6):735-7.
PMID: 2842065
There are no citations that match your criteria.
Customer Reviews for Cultrex Basement Membrane Extract, PathClear (8)
Customer Images
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Verified Customer | Posted 05/25/2023
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Verified Customer | Posted 05/15/2023
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Verified Customer | Posted 11/06/2022
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Verified Customer | Posted 05/23/2022Used for 3D culture experiments. Went very well
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Verified Customer | Posted 02/01/2022for 3D cell culture
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Application: In vivo studyVerified Customer | Posted 08/20/2018
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Application: Cell migration/motilityVerified Customer | Posted 04/01/2018
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Application: Cell ProliferationVerified Customer | Posted 04/01/2018
There are no reviews that match your criteria.
FAQs for Cultrex Basement Membrane Extract, PathClear
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What kinds of tumor cells or biopsy specimens grow in vivo with Cultrex® BME?
Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow in vivo when implanted with Cultrex® BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.
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How does Cultrex® Basement Membrane Extract (BME) promote cell differentiation?
All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix in vitro as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.
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How should Cultrex Basement Membrane Extract (BME) be stored and handled?
Cultrex BME should be stored at or below -20°C for optimal stability. Preparation of working aliquots is recommended. Cultrex BME should be thawed overnight on ice at 4°C, however long term storage at 4°C is not recommended. Freeze/thaw cycles and gel-liquid phase transitions should be avoided, since they can compromise product integrity.
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What is the percent of Laminin I in Cultrex® Basement Membrane Extract, PathClear, Catalog # 3432-010-01?
Cultrex® Basement Membrane Extract (BME), Pathclear, is composed of ≤ 60 % of Laminin I. Laminin is the major component of Cultrex BME. Other components are Collagen IV, which makes up ≤ 40% and Entactin which makes up ≤ 10%.