Cultrex Basement Membrane Extract, PathClear

Catalog # 3432-010-01 | R&D Systems, Inc. a Bio-Techne Brand
Basement Membrane Extract for use in multiple culture applications

Key Product Details

Features: Cultrex Basement Membrane Extract (BME) is an extracellular matrix hydrogel that has been used extensively in general cell culture applications to study cell attachment, proliferation, and invasion.
Key Benefits:
  • Ideal for general cell culture application
  • Polymerizes at 37°C to form a reconstituted basement membrane
  • Quality controlled for peformance consistency
Cultrex Basement Membrane Extract
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3432-001-01
3432-005-01
3432-010-01
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Setting the standard in quality research reagents
  • Preparation & Storage

    • Preparation & Storage

    Stability Product is stable for at least two years from date of manufacture when stored at ≤ -70 °C. See lot specific Certificate of Analysis for expiration date.
    Shipping Conditions The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
    Storage Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • Citations
  • Reviews
  • FAQs

    • Citations for Cultrex Basement Membrane Extract, PathClear (46)

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    Customer Reviews for Cultrex Basement Membrane Extract, PathClear (8)

    4.9 out of 5
    8 customer ratings
    5 stars
    88%
    4 stars
    13%
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    • Cultrex Basement Membrane Extract, PathClear
      Name: Anonymous
      Verified Customer | Posted 05/25/2023
      Cultrex Basement Membrane Extract, PathClear 3432-010-01
    • Cultrex Basement Membrane Extract, PathClear
      Name: Anonymous
      Verified Customer | Posted 05/15/2023
      Cultrex Basement Membrane Extract, PathClear 3432-010-01
    • Cultrex Basement Membrane Extract, PathClear
      Name: Anonymous
      Verified Customer | Posted 11/06/2022
      Cultrex Basement Membrane Extract, PathClear 3432-010-01
    • Cultrex Basement Membrane Extract, PathClear
      Name: Anonymous
      Verified Customer | Posted 05/23/2022
      Used for 3D culture experiments. Went very well
      Cultrex Basement Membrane Extract, PathClear 3432-010-01
    • Cultrex Basement Membrane Extract, PathClear
      Name: Anonymous
      Verified Customer | Posted 02/01/2022
      for 3D cell culture
      Cultrex Basement Membrane Extract, PathClear 3432-010-01
    • Cultrex PathClear Basement Membrane Extract (2 x 5 mL)
      Name: Anonymous
      Application: In vivo study
      Verified Customer | Posted 08/20/2018
    • Cultrex PathClear Basement Membrane Extract
      Name: Leslie Priddy
      Application: Cell migration/motility
      Verified Customer | Posted 04/01/2018
    • Cultrex PathClear Basement Membrane Extract
      Name: Leslie Priddy
      Application: Cell Proliferation
      Verified Customer | Posted 04/01/2018

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    FAQs for Cultrex Basement Membrane Extract, PathClear

    • What kinds of tumor cells or biopsy specimens grow in vivo with Cultrex® BME?

      Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow in vivo when implanted with Cultrex® BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.

    • How does Cultrex® Basement Membrane Extract (BME) promote cell differentiation?

      All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix in vitro as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.

    • How should Cultrex Basement Membrane Extract (BME) be stored and handled?

      Cultrex BME should be stored at or below -20°C for optimal stability. Preparation of working aliquots is recommended. Cultrex BME should be thawed overnight on ice at 4°C, however long term storage at 4°C is not recommended. Freeze/thaw cycles and gel-liquid phase transitions should be avoided, since they can compromise product integrity.

    • What is the percent of Laminin I in Cultrex® Basement Membrane Extract, PathClear, Catalog # 3432-010-01?

      Cultrex® Basement Membrane Extract (BME), Pathclear, is composed of ≤ 60 % of Laminin I. Laminin is the major component of Cultrex BME. Other components are Collagen IV, which makes up ≤ 40% and Entactin which makes up ≤ 10%.

    Product Documents for Cultrex Basement Membrane Extract, PathClear

    Certificate of Analysis

    To download a Certificate of Analysis, please enter a lot number in the search box below.

    Note: Certificate of Analysis not available for kit components.

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