Yoda 1

Product Description

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca²⁺-dependent chromatin hypercondensation and alters Ca²⁺-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca²⁺ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca²⁺ influx and K⁺ and water efflux, causing shrinkage of the cells.

Solubility

Preparing Stock Solutions for Yoda 1

The following data is based on the product molecular weight 355.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.07 mL	70.37 mL	140.74 mL
1 mM	2.81 mL	14.07 mL	28.15 mL
2 mM	1.41 mL	7.04 mL	14.07 mL
10 mM	0.28 mL	1.41 mL	2.81 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cahalan Piezo1 links mechanical forces to red blood cell volume. Elife. 2015 PMID: 26001274
• Mikhailov Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine? Neuropharmacology 2019 PMID: 30768945
• Jetta Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells. J.Cell Sci. 2019 PMID: 31076516
• Syeda Chemical activation of the mechanotransduction channel Piezo1. ELife 2015 PMID:  26001275