SR 3677 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3667
Potent, selective Rho-kinase (ROCK) inhibitor
Discontinued Product
3667 has been discontinued.
View all Rho-kinase Inhibitors products.
Key Product Details
Description
Potent, selective Rho-kinase (ROCK) inhibitor
Product Description
SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).Product Specifications
Molecular Weight
481.37
Formula
C22H24N4O4.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
CAS Number
1781628-88-3
PubChem ID
90255168
InChI Key
INVVXEKRUDMEBE-UHFFFAOYSA-N
SMILES
O=C(C3COC(C=CC=C4)=C4O3)NC1=CC=C(C2=CNN=C2)C=C1OCCN(C)C.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.49 | 100 | |
| DMSO | 44.49 | 100 |
Preparing Stock Solutions
for SR 3677 dihydrochloride
The following data is based on the product molecular weight 481.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.39 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Feng Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 2008 PMID: 18834107
Product Specific Notices for SR 3677 dihydrochloride
For research use only
Loading...
Loading...