(RS)-PPG
Tocris Bioscience, part of Bio-Techne | Catalog # 1220
Potent and selective mGlu8 agonist
Discontinued Product
1220 has been discontinued.
View all Group III mGluR Agonists products.
Key Product Details
Description
Potent and selective mGlu8 agonist
Product Description
(RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo.Product Specifications
Molecular Weight
231.14
Formula
C8H10NO5P
Storage
Store at RT
Chemical Name
(RS)-4-Phosphonophenylglycine
CAS Number
120667-15-4
PubChem ID
4545574
InChI Key
JRQRKFDFHAPMGQ-UHFFFAOYSA-N
SMILES
NC(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 23.11 | 100 |
Preparing Stock Solutions
for (RS)-PPG
The following data is based on the product molecular weight 231.14
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.33 mL | 21.63 mL | 43.26 mL |
| 5 mM | 0.87 mL | 4.33 mL | 8.65 mL |
| 10 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gasparini (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J.Pharmacol.Exp.Ther. 1999 PMID: 10336568
- Flor Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist. Soc.Neurosci.Abstr.
- Bigge Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-MthD.-aspartic acid antagonists. J.Med.Chem. 1989 PMID: 2544728
Product Specific Notices for (RS)-PPG
For research use only
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