Rec 15/2615 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3284
Selective α1B antagonist
Discontinued Product
3284 has been discontinued.
View all Adrenergic alpha-1 Receptor Antagonists products.
Key Product Details
Description
Selective α1B antagonist
Product Description
Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).Product Specifications
Molecular Weight
568.49
Formula
C26H33N5O5.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]piperazine dihydrochloride
CAS Number
1782573-48-1
PubChem ID
56972225
InChI Key
XZGSTPYGKYGQLD-UHFFFAOYSA-N
SMILES
NC2=NC(N3CCN(C(COC4=C(OC)C=CC=C4C(C)C)=O)CC3)=NC1=CC(OC)=C(OC)C=C12.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.85 | 100 |
Preparing Stock Solutions
for Rec 15/2615 dihydrochloride
The following data is based on the product molecular weight 568.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.76 mL | 8.80 mL | 17.59 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bremner Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 2000 PMID: 10968279
- Morston α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 2007 PMID: 17115072
- Testa Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 1997 PMID: 9190864
Product Specific Notices for Rec 15/2615 dihydrochloride
For research use only
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