MS 245 oxalate
Tocris Bioscience, part of Bio-Techne | Catalog # 4208
High affinity 5-HT6 antagonist
Discontinued Product
4208 has been discontinued.
View all 5-HT6 Receptor Antagonists products.
Key Product Details
Description
High affinity 5-HT6 antagonist
Product Description
MS 245 oxalate is a high affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.Product Specifications
Molecular Weight
448.49
Formula
C19H22N2O3S.C2H2O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
CAS Number
275363-58-1
PubChem ID
6918541
InChI Key
BLSWAEGCRSFTJG-UHFFFAOYSA-N
SMILES
O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.42 | 50 |
Preparing Stock Solutions
for MS 245 oxalate
The following data is based on the product molecular weight 448.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.46 mL | 22.30 mL | 44.59 mL |
| 2.5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Young Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 2006 PMID: 16950502
- Dukat Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 2008 PMID: 18201064
- Nirogi Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett.
- Glennon 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 2000 PMID: 10715164
Product Specific Notices for MS 245 oxalate
For research use only
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