L-690,488
Tocris Bioscience, part of Bio-Techne | Catalog # 0682
Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Discontinued Product
0682 has been discontinued.
View all Inositol Lipid Inhibitors products.
Key Product Details
Description
Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Product Description
L-690,488 is a cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
754.70
Formula
C32H52O16P2
Storage
Store at -80°C
Purity
≥98% (HPLC)
Chemical Name
1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
CAS Number
142523-14-6
PubChem ID
5132514
InChI Key
LOTSPVPQHAUHCE-UHFFFAOYSA-N
SMILES
OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 75.47 | 100 | |
| Ethanol | 75.47 | 100 |
Preparing Stock Solutions
for L-690,488
The following data is based on the product molecular weight 754.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.33 mL | 6.63 mL | 13.25 mL |
| 5 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 10 mM | 0.13 mL | 0.66 mL | 1.33 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.27 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen Stimulatory effect of Li on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 1998 PMID: 9688629
- Atack Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 1994 PMID: 8035344
Product Specific Notices for L-690,488
For research use only
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