DMAB-anabaseine dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2241
Partial agonist at α7 nAChR; also α4β2 antagonist
Discontinued Product
2241 has been discontinued.
View all Nicotinic (a7) Receptor Agonists products.
Key Product Details
Description
Partial agonist at α7 nAChR; also α4β2 antagonist
Product Description
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.Product Specifications
Molecular Weight
364.32
Formula
C19H21N3.2HCl
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
CAS Number
154149-38-9
PubChem ID
16759167
InChI Key
DHCNEWWWKHBASC-YNHPUKFJSA-N
SMILES
CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 36.43 | 100 | |
| DMSO | 9.11 | 25 |
Preparing Stock Solutions
for DMAB-anabaseine dihydrochloride
The following data is based on the product molecular weight 364.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.45 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kem Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9399967
- Stevens Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 1998 PMID: 9600576
- Arendash Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 1995 PMID: 7796104
Product Specific Notices for DMAB-anabaseine dihydrochloride
For research use only
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