(±)-AC 7954 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2484
Non-peptide UT receptor agonist
Discontinued Product
2484 has been discontinued.
View all Urotensin-II Receptor Agonists products.
Key Product Details
Description
Non-peptide UT receptor agonist
Product Description
(±)-AC 7954 hydrochloride is a highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).Product Specifications
Molecular Weight
366.28
Formula
C19H20ClNO2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
CAS Number
477313-09-0
PubChem ID
9907171
InChI Key
AJPGLOWFIBOGMH-UHFFFAOYSA-N
SMILES
Cl.CN(C)CCC1(CC2=CC=CC=C2C(=O)O1)C1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.47 | 75 | |
| DMSO | 27.47 | 75 |
Preparing Stock Solutions
for (±)-AC 7954 hydrochloride
The following data is based on the product molecular weight 366.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.64 mL | 18.20 mL | 36.40 mL |
| 3.75 mM | 0.73 mL | 3.64 mL | 7.28 mL |
| 7.5 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 37.5 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lavecchia Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 2005 PMID: 15801838
- Lehmann Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 2006 PMID: 16570919
- Croston Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 2002 PMID: 12408704
Product Specific Notices for (±)-AC 7954 hydrochloride
For research use only
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