Key Product Details
Glu2-Glu222, with an N-terminal Met and 6-His tag
Accession # P70202
N-terminal Sequence Analysis
Predicted Molecular Mass
The IC50 value is
Formulation, Preparation and Storage
|Formulation||Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.|
|Shipping||The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Latexin, also known as tissue carboxypeptidase inhibitor, is the only mammalian carboxypeptidase inhibitor identified so far. Latexin was initially identified as a marker of neurons in the lateral neocortex of the developing brain (hence Latexin) (1). Further studies have shown that Latexin is highly expressed in mast cells and macrophages (2, 3). It is induced in acute pancreatitis and lung inflammatory disease. In addition, it is able to inhibit carboxypeptidases from the pancreas (CPA1 and CPA2) and mast cells (CPA3) (4). Therefore, it is thought that Latexin primarily functions in inflammation and innate immunity pathways. Compared to other carboxypeptidase inhibitors from plants and parasites, the 222 amino acid Latexin is much larger and more importantly, it lacks some conserved C-terminal residues, which interact with the target carboxypeptidase in a substrate-like manner (5). This distinct feature of Latexin suggests that it has a different carboxypeptidase inhibition mechanism.
- Arimatsu, Y. et al. (1994) Neurosci. Res. 20:131.
- Uratani, Y. et al. (2000) Biochem. J. 346:817.
- Aagaard A. et al. (2005) Structure 13:309.
- Normant E. et al. (1995) Proc. Natl. Acad. Sci. USA 92:12225.
- Reverter D. et al. (2000) Nat. Struct. Biol. 7:322.
Product Specific Notices for Recombinant Mouse Latexin Protein, CF
For research use only