Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC3200
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Transglutaminase 3/TGM3
Transglutaminase 3 (TG3), also known as epidermal Transglutaminase (Tgase E), belongs to the family of Transglutaminase enzymes that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions. TG3 is involved in the formation of the cornified envelope in skin keratinocytes. It functions to cross-link structural proteins during epidermal terminal differentiation. TG3 has been implicated as the dominant autoantigen in dermatitis herpetiformis. TG3 activation requires proteolysis of the 77 kDa zymogen into two fragments of approximately 50 and 27 kDa to form the active enzyme.
Alternate Names
TG3, TgaseE, TGM3
Gene Symbol
TGM3
UniProt
Additional Transglutaminase 3/TGM3 Products
Product Documents for Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA
Product Specific Notices for Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA
For research use only
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