Thrombopoietin R/Tpo R Antibody (24GB470)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50528

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NBP3-50528-100ul
NBP3-50528-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB470

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Thrombopoietin R/Tpo R Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Thrombopoietin R/Tpo R (Uniprot: P40238)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Thrombopoietin R/Tpo R Antibody (24GB470)

Thrombopoietin R/Tpo R Antibody (24GB470)

Immunocytochemistry/ Immunofluorescence: Thrombopoietin R/Tpo R Antibody (24GB470)[NBP3-50528] -

Immunocytochemical staining of HepG2 cells with Thrombopoietin R/Tpo R antibody (1:1,000). Nuclei were stained blue with DAPI; Thrombopoietin R/Tpo R was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
Thrombopoietin R/Tpo R Antibody (24GB470)

Flow Cytometry: Thrombopoietin R/Tpo R Antibody (24GB470)[NBP3-50528] -

Flow cytometric analysis of Thrombopoietin R/Tpo Rexpression in HepG2 cells using Thrombopoietin R/Tpo R antibody (1:2,000). Green, isotype control; red, MPL.
Thrombopoietin R/Tpo R Antibody (24GB470)

Western Blot: Thrombopoietin R/Tpo R Antibody (24GB470)[NBP3-50528] -

Western blotting analysis using Thrombopoietin R/Tpo R antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Thrombopoietin R/Tpo R Antibody (24GB470)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Thrombopoietin R/Tpo R

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq]

Long Name

Thrombopoietin Receptor

Alternate Names

c-Mpl, CD110, MPL, MPLV, TpoR

Gene Symbol

MPL

Additional Thrombopoietin R/Tpo R Products

Product Documents for Thrombopoietin R/Tpo R Antibody (24GB470)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Thrombopoietin R/Tpo R Antibody (24GB470)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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