Porimin Antibody (CL14381) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26852

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # CL14381

Format

BSA Free

Concentration

1 mg/ml

View all Porimin Antibodies »

Product Specifications

Immunogen

This antibody was developed using a synthetic peptide derived from Q8N131, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Description

Novus Biologicals Mouse Porimin Antibody (CL14381) - BSA Free (NBP3-26852) is a monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Porimin Antibody (CL14381) - BSA Free

Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Staining of human testis shows moderate to strong cytoplasmic positivity in cells in seminiferous ducts.
Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Analysis in human tonsil and skeletal muscle tissues. Corresponding RNA-seq data are presented for the same tissues.
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Applications for Porimin Antibody (CL14381) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Porimin

Porimin was identified by a monoclonal antibody developed by immunizing mice with apoptotic cells. One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells by binding to a 110-kDa cell surface receptor on Jurkat cells. Anti-Porimin-mediated cell death was preceded by cell aggregation, formation of plasma membrane pores, and the appearance of membrane blebs. More important, these cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell membrane.

Long Name

Pro-Oncosis Receptor Inducing Membrane Injury

Alternate Names

KCT3, TMEM123

Gene Symbol

TMEM123

Additional Porimin Products

Product Documents for Porimin Antibody (CL14381) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Porimin Antibody (CL14381) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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