Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27001
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # PVALB/7601
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
Recombinant fragment (around aa1-110) of human Parvalbumin alpha protein (exact sequence is proprietary)
Localization
Nucleus, Cell junctions
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Description
Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.
Scientific Data Images for Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free
Immunohistochemistry-Paraffin: Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free [NBP3-27001] -
Formalin-fixed, paraffin-embedded human kidney stained with Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free. Inset: PBS instead of primary antibody; secondary only negative control.Applications for Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free
Application
Recommended Usage
Immunohistochemistry-Paraffin
1-2ug/ml for 30 minutes at RT
Application Notes
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
10mM PBS
Format
Azide and BSA Free
Preservative
No Preservative
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Background: Parvalbumin alpha
Parvalbumin alpha is a 12 kDa member of the parvalbumin family of Ca2+-binding proteins. In human, it is expressed in intrafusal muscle fibers, plus GABAergic interneurons and cerebellar Purkinje and basket cells. It presumably acts as a Ca2+ buffer that shortens the duration of fiber contraction. Human Parvalbumin is 110 amino acids (aa) in length. It contains two EF-hand domains (aa 39 - 74 and 78 - 110) that bind calcium. There are three potential isoform variants. One shows an alternate start site at Met33, a second shows a six aa substitution for the C-terminal nine amino acids and a third shows a deletion of Gly99 - Val100. Human Parvalbumin alpha is 51% aa identical to human Parvalbumin beta and is 87% plus 92% aa identical to mouse and rat Parvalbumin, respectively.
Alternate Names
PVALB
Gene Symbol
PVALB
Additional Parvalbumin alpha Products
Product Documents for Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free
Product Specific Notices for Parvalbumin alpha Antibody (PVALB/7601) - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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