Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Primate, Xenopus

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 184C278

Format

BSA Free

Concentration

0.5 mg/ml

View all NKIRAS1 Antibodies »

Product Specifications

Immunogen

This monoclonal antibody was raised against a synthetic peptide containing amino acid residues 96-113 (RVELLKKEIDKFKDKKEV) of human kB-Ras1.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for NKIRAS1 Antibody (184C278) - BSA Free

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555] - Analysis of human 293 cell lysate probed using 0.5 ug/ml. Image using the Azide Free form of this antibody.
Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555] - Analysis of NKIRAS1 using this antibody. Human 293 cell lysate probed with kB-Ras1 antibody at 0.5 ug/ml.

Applications for NKIRAS1 Antibody (184C278) - BSA Free

Application
Recommended Usage

Western Blot

0.5-1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NKIRAS1

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.

Alternate Names

I-kappa-B-interacting Ras-like protein 1, kappa B-ras 1, Kappa B-Ras protein 1, KappaB-Ras1, KBRAS1kappaB-Ras1, NF-kappa-B inhibitor-interacting Ras-like protein 1, NFKB inhibitor interacting Ras-like 1, NFKB inhibitor interacting Ras-like protein 1

Entrez Gene IDs

28512 (Human)

Gene Symbol

NKIRAS1

UniProt

Q9NYS0 (Human)

Additional NKIRAS1 Products

Product Documents for NKIRAS1 Antibody (184C278) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for NKIRAS1 Antibody (184C278) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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