Mouse CD11c APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB69501A

Discontinued Product
FAB69501A has been discontinued. View all CD11c products.

Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Hamster IgG Clone # N418

View all CD11c Antibodies »

Product Specifications

Immunogen

Mouse spleen dendritic cells

Specificity

Detects mouse Integrin alphaX/CD11c.

Clonality

Monoclonal

Host

Hamster

Isotype

IgG

Scientific Data Images for Mouse CD11c APC-conjugated Antibody

Detection of CD11c antibody in Mouse Splenocytes antibody by Flow Cytometry.

Detection of CD11c in Mouse Splenocytes by Flow Cytometry.

Mouse splenocytes were stained with Rat Anti-Mouse MHC class II (I-A/I-E) Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB6118F) and either (A) Hamster Anti-Mouse CD11c APC-conjugated Monoclonal Antibody (Catalog # FAB69501A) or (B) Hamster IgG Allophycocyanin Control. View our protocol for Staining Membrane-associated Proteins.

Applications for Mouse CD11c APC-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Mouse splenocytes

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Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD11c

The Integrin alphaX subunit, also known as CD11c, is a 150 kDa type I transmembrane protein that noncovalently heterodimerizes with the beta2 subunit (CD18) to form alphaX/ beta2, also known as p150/p95 and complement receptor type 4 (CR4). Integrin alphaX beta2 is expressed on macrophages, dendritic cells, hairy cell leukemias and some other leukocyte subsets. The 1097 aa mouse alphaX extracellular domain shares 71% and 87% amino acid (aa) identity with human and rat alphaX, respectively. One potential alphaX isoform is truncated at aa 828. Some adhesion partners of alphaX beta2 are shared with alphaM beta2/CD11b/CD18 (complement iC3b, ICAMs, vWF and fibrinogen) while others (osteopontin, Thy-1, plasminogen, heparin) are unique. Unlike alphaM beta2, it is not constitutively active. alphaX beta2 adhesion mediates proliferation, degranulation, chemotactic migration, and phagocytosis of complement-opsonized particles.

References

  1. Metlay, J.P. et al. (1990) J. Exp. Med. 171:1753.

Alternate Names

CD11c, Integrin alpha X, ITGAX, p150,95 alpha

Entrez Gene IDs

3687 (Human); 16411 (Mouse); 64350 (Rat)

Gene Symbol

ITGAX

Additional CD11c Products

Product Documents for Mouse CD11c APC-conjugated Antibody

Product Datasheets

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Product Specific Notices for Mouse CD11c APC-conjugated Antibody

For research use only

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