Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1117503

View all SLC25A28 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for human SLC25A28 around amino acid 250 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SLC25A28

Solute carrier 25 member 28 (SLC25A28) is a mitochondrial carrier protein, categorized within the solute carrier family. This protein plays an essential role in mitochondrial iron transport and homeostasis, which is crucial for maintaining oxidative phosphorylation and overall cellular energy metabolism. SLC25A28 is predominantly involved in iron export from mitochondria to the cytosol, facilitating optimal levels of iron-sulfur cluster formation and heme biosynthesis. The dysfunction or dysregulation of SLC25A28 can lead to significant cellular disturbances, including oxidative stress and impaired mitochondrial function, both of which have been linked to neurodegenerative diseases and other metabolic disorders. Moreover, mutations in the SLC25A28 gene have been implicated in diseases like sideroblastic anemia and mitochondrial iron-loading disorders, demonstrating its central role in systemic iron regulation. Given its critical functions in cellular metabolism and iron homeostasis, SLC25A28 has emerged as a promising biomarker for metabolic and mitochondrial pathologies, with potential therapeutic implications in iron-related disease management.

References

  1. Kunji ERS, King MS, Ruprecht JJ, Thangaratnarajah C. The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology. Physiology (Bethesda). 2020 Sep 1;35(5):302-327. doi: 10.1152/physiol.00009.2020. PMID: 32783608; PMCID: PMC7611780.2. 
  2. Guan H, Xiao L, Hao K, Zhang Q, Wu D, Geng Z, Duan B, Dai H, Xu R, Feng X. SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL. J Diabetes Res. 2024 May 4;2024:5511454. doi: 10.1155/2024/5511454. PMID: 38736904; PMCID: PMC11088465.

Long Name

solute carrier family 25 member 28

Alternate Names

MFRN2, MRS3/4, MRS4L, NPD016

Entrez Gene IDs

81894 (Human); 246696 (Mouse); 688811 (Rat)

Gene Symbol

SLC25A28

UniProt

Q96A46 (Human)

Additional SLC25A28 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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