The human FAIM3 gene (also known as FCMR or TOSO), is a transmembrane sialoglycoprotein expressed mainly by lymphocytes. FAIM3 is a type I membrane protein with an intracellular C-terminal domain and an extracellular N-terminal domain (1). The extracellular domain has homology to the immunoglobulin variable region domains (1) and FAIM3 is identified as an Fc receptor for IgM (2, 3). The amino acid sequence of human FAIM3 is 58% and 55% identical to that of mouse and rat FAIM3, respectively. FAIM3 was shown to be over-expressed in chronic lymphocytic leukemia (CLL) (4) and associated with disease progression (5, 6). FAIM3 has also been linked to the homeostasis and activation of the innate immune system (7). Interestingly, there is growing evidence that neurodegenerative diseases are associated with the activation of the immune surveillance system. This system is responsible for controlling danger signals and responding accordingly to the magnitude and duration of the threat (8, 9).

References

Song, Y. et al (2005) J. Biol. Chem. 280(10):9618.
Shima H et al. (2010) Int. Immunol. 22:149.
Kubagawa H et al. (2009) J. Exp. Med. 206:2779.
Proto-Siqueira R et al. (2008) Blood, 112:394.
Pallasch, C et al. (2008) Blood, 112:4213.
Pallasch, C P et al (2009) Leukemia & lymphoma, 50:498.
Sigruener, A et al (2007) Biochemical and biophysical research communications, 359:723.
Richards R I et al (2016) Front. Neurosci. 10:193.
Planells-Ferrer L et al (2016) J Neurochem. 139:11.

Long Name

Fc mu Receptor

Alternate Names

FAIM3, FCMR, Toso

Entrez Gene IDs

9214 (Human); 69169 (Mouse); 548326 (Rat)

Gene Symbol

FCMR

UniProt

O60667

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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human/Mouse/Rat Fc mu R/FAIM3 Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9494AFP680

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Background: Fc mu R/FAIM3