Human MAVS Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB9694AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Monoclonal Mouse IgG2B Clone # 981240
Product Specifications
Immunogen
E.coli-derived recombinant human MAVS
Specificity
Detects human MAVS in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Applications for Human MAVS Alexa Fluor™ Plus 680-conjugated Antibody
Application
Recommended Usage
Immunohistochemistry
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: MAVS
Mitochondrial antviral signaling protein (MAVS, also known as IPS-1, VISA, and CARDIF) is a ubiquitous, tail-anchored membrane protein inserted in the outer mitochondrial membrane (OMM), and is also found in the peroxisomal membrane and the mitochondrial associated membrane of the endoplasmic reticulum. Peroxisomal MAVS has been implicated in type II IFN-dependent antiviral response, while mitochondrial MAVS mediates longer lasting type I IFN dependent antiviral response. Mitochondrial reactive oxygen species (mROS) induce oligomerization of MAVS in the outer membrane plane of mitochondria to induce innate immunity to viral infection. MAVS undergoes RIG-I-like receptors (RLR)-induced formation of higher order structures ranging from dimers to prion-like aggregates that lead to the recruitment and activation of signaling proteins culminating in the activation of the transcription factors IRF-3 and NF-kappa B and transcription of IFNs
Long Name
Mitochondrial Antiviral Signaling Protein
Alternate Names
Cardif, IPS-1, VISA
Gene Symbol
MAVS
UniProt
Additional MAVS Products
Product Specific Notices for Human MAVS Alexa Fluor™ Plus 680-conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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