Detects human LINGO-1 in direct ELISA and Western blot. In direct ELISA and Western blot, approximately 10% cross-reactivity with recombinant human (rh) LINGO-2 is observed and no cross-reactivity with rhLINGO-3 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Scientific Data Images for Human LINGO-1 APC-conjugated Antibody

Detection of LINGO‑1 in A172 Human Cell Line by Flow Cytometry.

A172 human glioblastoma cell line was stained with Mouse Anti-Human LINGO-1 APC-conjugated Monoclonal Antibody (Catalog # FAB30861A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human LINGO-1 APC-conjugated Antibody

Application

Recommended Usage

Flow Cytometry

10 µL/10⁶ cells
Sample: A172 human glioblastoma cell line

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: LINGO-1

LINGO-1 (LRRN6A) is a 614 amino acid (aa) transmembrane protein of the leucine-rich repeat (LRR) family, ribonuclease inhibitor subfamily. The four known LINGO proteins contain LRR and IgCAM domains in the extracellular portion and share 44‑61% aa sequence identity. LINGO-1 is restricted to the nervous system and is concentrated in the brain as a component of the NgR1/p75 and NgR1/Taj (TROY) signaling complexes. LINGO-1 negatively regulates neurite outgrowth and myelination. LINGO-1 is highly conserved, showing 99% aa sequence identity between human, mouse and rat.

Long Name

Leucine-rich Repeat And Ig Domain Containing Nogo Receptor-Interacting Protein 1

Alternate Names

LERN1, LINGO1, LRRN6A

Entrez Gene IDs

84894 (Human)

Gene Symbol

LINGO1

UniProt

NP_116197

Additional LINGO-1 Products

Product Documents for Human LINGO-1 APC-conjugated Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human LINGO-1 APC-conjugated Antibody

For research use only

Citations
Reviews

Human LINGO-1 APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB30861A

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

View all LINGO-1 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Scientific Data Images for Human LINGO-1 APC-conjugated Antibody

Detection of LINGO‑1 in A172 Human Cell Line by Flow Cytometry.

Applications for Human LINGO-1 APC-conjugated Antibody

Flow Cytometry

Spectra Viewer

Plan Your Experiments

Formulation, Preparation, and Storage

Purification

Formulation

Shipping

Stability & Storage

Background: LINGO-1

Long Name

Alternate Names

Entrez Gene IDs

Gene Symbol

UniProt

Additional LINGO-1 Products

Product Documents for Human LINGO-1 APC-conjugated Antibody

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for Human LINGO-1 APC-conjugated Antibody

CONTACT INFORMATION

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