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Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Lgr5/GPR49

GPR49 (G-protein-coupled receptor 49), also called LGR5 (leucine-rich repeat GPR 5) is a seven-transmembrane glycoprotein receptor that negatively regulates of Wnt signaling in the developing intestine. Expression of GPR49 is upregulated in intestinal stem cells and intestinal cancer stem cells and promotes carcinogenesis. GPR49 cDNA encodes 907 amino acids (aa), including a long N-terminal extracellular domain (aa 22-561) with 16 LRR domains. Human GPR49 shares 90% aa sequence identity with mouse and rat GPR45 within aa 22-561.

Long Name

Leucine-rich Repeat Containing G Protein-coupled Receptor 5

Alternate Names

FEX, GPR49, GPR67, HG38

Entrez Gene IDs

8549 (Human); 14160 (Mouse); 299802 (Rat); 102120216 (Cynomolgus Monkey)

Gene Symbol

LGR5

UniProt

O75473 (Human)

Additional Lgr5/GPR49 Products

Product Documents

Product Datasheets

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COA

SDS

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Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Citations
Reviews

Human Lgr5/GPR49 Alexa Fluor™ Plus 555-conjugated MAb (Clone 750835)

R&D Systems, part of Bio-Techne | Catalog # FAB80781AFP555

Key Product Details

Species Reactivity

Applications

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Antibody Source

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Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype