Human Jarid1A/KDM5A Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11705AFP680

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FAB11705AFP680-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 1102542

View all Jarid1A Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Jarid1A/KDM5A

Specificity

Detects recombinant human Jarid1A/KDM5a protein in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Jarid1A

Jarid1A (also known as KDM5A) is a protein of approximately 175kDa that belongs to the Jumonji/ARID1 (JARID) protein family. It functions primarily as a lysine demethylase, involved in the regulation of histone H3 lysine 4 (H3K4) demethylation, thereby playing a crucial role in chromatin remodeling and epigenetic regulation. Jarid1A is implicated in multiple biological processes, including cell cycle progression, differentiation, and development. Dysregulation of Jarid1A is associated with various pathologies, particularly its overexpression in several types of cancer, where it contributes to tumorigenesis, cancer cell proliferation, and metastasis. It is also linked to altered gene expression profiles in neurological disorders. The role of Jarid1A in transcriptional regulation highlights its potential as a therapeutic target and biomarker for cancer and other diseases involving epigenetic dysregulation.

References

  1. Harmeyer KM, Facompre ND, Herlyn M, Basu D. JARID1 Histone Demethylases: Emerging Targets in Cancer. Trends Cancer. 2017 Oct;3(10):713-725. doi: 10.1016/j.trecan.2017.08.004. Epub 2017 Sep 12. PMID: 28958389; PMCID: PMC5679451. 
  2. Yang GJ, Zhu MH, Lu XJ, Liu YJ, Lu JF, Leung CH, Ma DL, Chen J. The emerging role of KDM5A in human cancer. J Hematol Oncol. 2021 Feb 17;14(1):30. doi: 10.1186/s13045-021-01041-1. PMID: 33596982; PMCID: PMC7888121.

Long Name

Lysine-specific demethylase 5A

Alternate Names

EC 1.14.11.67, KDM5A, RBBP-2, RBBP2, RBP2

Entrez Gene IDs

5927 (Human); 214899 (Mouse)

Gene Symbol

KDM5A

UniProt

P29375 (Mouse)

Additional Jarid1A Products

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Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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