G-protein coupled receptor 158 (GPR158) is a receptor belonging to the Class C GPCR family. It lacks the extracellular Venus flytrap module characteristic of the known members of that family and instead contains two other elements that are not typical of the class: a calcium-binding EGF-like domain and a leucine repeat region (1, 2). The mature extracellular domain of human GPR158 contains 393 amino acids (aa) and shares 89% identity with both mouse and rat GPR158. GPR158 is expressed at the highest level in the brain, but also in a variety of other tissues including retina, spleen, liver and lung (3). GPR158 was originally identified in functional screens linked with biological stress and has been implicated in the osteocalcin effect on cognitive processes in the brain (4, 5), and glaucoma and cancer in the periphery (4, 6).

References

Jingami, H. et al. (2003) Curr. Opin. Neurobiol. 13:271.
Bjarnadóttir, T.K et al. (2005) Gene. 362:70.
Orlandi, C. et al. (2012) J. Cell Biol. 197:711.
Itakura, T. et al. (2019) J. Ocul. Pharmacol. Ther. 35:203.
Khrimian, L. et al. (2017) J. Exp. Med. 214:2859.
Fenner, A. (2015) Nat. Rev. Urol. 12:182.

Alternate Names

KIAA1136, RP11-59G22.1

Entrez Gene IDs

57512 (Human); 241263 (Mouse); 291352 (Rat)

Gene Symbol

GPR158

UniProt

Q5T848

Additional GPR158 Products

Product Documents

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human GPR158 Alexa Fluor™ Plus 405-conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Citations
Reviews

Spectra Viewer
Flow Cytometry

Human GPR158 Alexa Fluor™ Plus 405-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB10286AFP405

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

View all GPR158 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for Human GPR158 Alexa Fluor™ Plus 405-conjugated Antibody

CyTOF-ready

Flow Cytometry

Immunohistochemistry

Western Blot

Formulation, Preparation, and Storage

Formulation

Shipping

Stability & Storage

Background: GPR158