Human CRBN Alexa Fluor® 647-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB9574R

Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Accession # Q96SW2
Specificity
Clonality
Host
Isotype
Applications for Human CRBN Alexa Fluor® 647-conjugated Antibody
Immunocytochemistry
Immunohistochemistry
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: CRBN
Cerbeblon (CRBN) is a substrate recognition component of an E3 protein ligase complex which mediates ubiquitination and proteasomal degradation of target proteins. In embryonic development, degradation of regulatory proteins is required for normal limb outgrowth. Thalidomide, a teratogenic drug prescribed to pregnant women in the 1950s, binds to CRBN in the E3 protein ligase complex. Despite its teratogenic effect, CRBN is used to treat multiple myeloma and complications of leprosy. Widely expressed, CRBN may play a role in memory and learning by regulating assembly and surface expression of large-conductance calcium-activated potassium channels in hippocampal neurons. Mutations in the CRBN gene is linked to the Mental Retardation, Autosomal Recessive2a (MR2A) form of mental retardation.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional CRBN Products
Product Documents for Human CRBN Alexa Fluor® 647-conjugated Antibody
Product Specific Notices for Human CRBN Alexa Fluor® 647-conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only