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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor 750 (Excitation = 749 nm, Emission = 775 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1022517

Product Specifications

Immunogen

Human embryonic kidney cell HEK293-derived CLCA1
Asn22-Ser477
Accession # A8K714

Specificity

Detects CLCA1 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human CLCA1 Alexa Fluor® 750-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CLCA1

CLCA1 is a member of the calcium sensitive chloride conductance protein family which may be involved in mediating calcium-activated chloride conductance.  This protein is expressed in goblet cells and intestinal basal crypt epithelial of the small intestine and colon. CLCA1 regulates mucin expression and participates in innate immune responses by binding to yet unidentified molecules on inflammatory cells for cytokine and chemokine production.  CLCA1 also targets lymphatic endothelial cells and cancer cells.  CLCA1 is a candidate as a modulating factor in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases including asthma, COPD, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection.

Long Name

Chloride Channel Accessory 1

Alternate Names

CaCC-1, CLCRG1, GOB5, HCLCA1

Entrez Gene IDs

1179 (Human); 23844 (Mouse); 308015 (Rat)

Gene Symbol

CLCA1

UniProt

Additional CLCA1 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CLCA1 Alexa Fluor® 750-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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